Parkinson’s disease is a neruodegenerative disorder that primarily affects the motor system. It is named after James Parkinson, the British physician who first described the condition in1817. Parkinson’s disease is characterised by a gradual loss of dopamine- producing cells in a region of the brain called the substantia Nigra.

Parkinson's disease symptoms

Motor symptoms typically include:

  1. Tremors: Shaking, often starting in one hand, fingers, sometimes jaw or face

  2. Bradykinesia: Slowed movement, making daily tasks more difficult. Difficulty initiating movement. Affecting buttoning or writing

  3. Rigidity: Muscle or joints stiffness affecting mobility and posture.

  4. Postural Instability: Balance issues and difficulty with coordination.

  5. Changes in Speech: Softer voice or slurred speech.

  6. Altered Gait: Shuffling walk or reduced arm swing.

Motor symptoms typically include:

  1. Cognitive Impairment: dementia, affecting memory, attention, executive function.

  2. Mood and Psychiatric: depression, anxiety and apathy

  3. Sleep Disturbances: insomnia, REM sleep behaviour

  4. Autonomic Dysfunction: orthostatic hypotension(a sudden drop in blood press upon standing), urinary problems. constipation, excessive sweating.

Symptoms can vary widely among individuals and may progress over time.

Unified Parkinson’s Disease Rating Scale UPDRS

This scale is a rating tool used to gauge Parkinson’s symptoms in patients

https://www.mdapp.co/unified-parkinson-s-disease-rating-scale-updrs-calculator-523/

The Modified Hoehn and Yahr staging system is a grading method used to evaluate the severity of Parkinson's disease in patients. It provides a simple tool to classify the progression of the disease from early to late stages, ranging from 0 to 5:

  • Stage 0: No symptoms.

  • Stage 1: Symptoms affect only one side of the body (unilateral symptoms), are mild, and have minimal impact on daily life.

  • Stage 1.5: Unilateral symptoms with trunk involvement; posture and balance are slightly affected.

  • Stage 2: Symptoms appear on both sides of the body (bilateral symptoms) but do not impair balance.

  • Stage 2.5: Bilateral symptoms with slight instability during balance testing, but no falls occur.

  • Stage 3: Bilateral symptoms with significant balance impairment, requiring assistance, but the patient can still walk and perform daily activities independently.

  • Stage 4: Severe symptoms requiring help from others to walk and perform daily activities.

  • Stage 5: Extremely severe, with patients largely unable to move independently and requiring a wheelchair or being bedridden.

This staging system helps healthcare professionals more accurately assess disease progression and develop personalized treatment plans tailored to the different stages.

Two effective Treatment for PD

  1. Scalp Acupuncture

  2. HDT Therapy


1 . Scalp Acupuncture

refer to microcurrent therapy & Scalp Acupuncture in this website



2 . HDT Therapy

High doses of thiamine (vitamin B1), devised by Dr. Antonio Costantini and his group, to relieve symptoms of Parkinson’s Disease, as well as those of several other neurodegenerative and autoimmune diseases listed below.

Clinical observation of patients suffering from a number of autoimmune and neurodegenerative diseases such as

  • Fibromyalgia,

  • Parkinson’s Disease,

  • Essential Tremor,

  • Spinocerebellar Ataxia Type 2,

  • Huntington Disease,

  • Cluster Headache,

  • Migraine,

  • Friedreich’s Ataxia ,

  • fatigue in Multiple Sclerosis,

  • inflammatory bowel disease,

  • fatigue after stroke,

  • Hashimoto’s thyroiditis,

  • Dystonia,

  • myototonic dystrophy,

  • chronic cluster headache,

  • and many more

suggests that the HDT protocol can be a powerful aid to classic therapy, enhancing benefits for the patient while also reducing collateral/side effects of traditional drugs.

Starting in 2011, Dr. Antonio Costantini, an Italian neurologist, began studying a therapeutic protocol to treat a number of symptoms in the diseases listed above.

HDT B1 Thiamine HCL Therapy

High-Dose Thiamine (HDT) therapy - Dr. Antonio Costantini Research

if Body weight 110-145lbs (~8-10stone, 50-66kg)

B1 Thiamine 2g /day

i.e. 1g before lunch and 1g after lunch,

if Body weight >145lbs (>10stone, 66kg)

B1 Thiamine 3g / day

i.e. 2g before lunch and 1g after lunch,

  • Within few days will has a significant change, both the non-motor and motor symptoms.

  • Oral thiamine should not be taken with juice, water only.

  • need to find the correct precise doses, let’s start with 2 or 3g

  • The correct dose of high-dose thiamine therapy reduces greatly the symptoms.

  • If the initial Dose Exceeds patient need, they will experience a worsening of the symptoms, halt the treatment with high dose thiamine for a week or so, and when the worsening regresses we restart the therapy with lower doses, often half the original dose.

  • Record video Before and After treatment

Summarizing, out of the 2,500+ patients Dr. Antonio Costantini have treated he found:

  • Relevant improvement of motor and non-motor symptoms;

  • The disease does not seem to progress;

  • Absence of insurgence of complications due to long-term use of L-dopa;

  • No collateral effects or alterations of the results of blood tests.

Quit Sugar (Synthetic)

  • Aspartame 阿斯巴甜

  • Saccharine 糖精

  • Sucralose 三氯蔗糖

  • Acesulfamek 乙酰磺胺酸鉀

  • white sugar 白糖

  • Agave Syrup 龍舌蘭糖槳*

  • Corn Syrup 粟米糖槳

  • The Below types of sugar are better 好小小但都差有以下

  • natural sugar天然糖

  • Coconut Suguar椰子糖

  • Dainer楓葉糖槳

  • Honey 蜜糖

Further Vitamin Dose Adjustment

Long-term high-dose B1 thiamine therapy (HDT) can lead to deficiencies in the absorption of other B vitamins, so it's necessary to take supplement with a B-complex.

The B complex should include B1, B2, B3, B5, B9, and B12.
However, B6 tends to accumulate in the body, so when choosing a B-complex, it is ideal for the B6 content to be less than 10mg.

Use the B-complex for 4 months, then stop for 2 months to prevent the accumulation of B6 (as B6 cannot be excreted via urine). The B-complex, including B1, B2, B3, B5, B9, and B12, can be excreted via urine.

Enhanced version of HDT protocol:

  • B1: 2g (eg. 4 tablets of 500mg B1)

  • 1 capsule of B complex and B12 (note that increasing B12 can affect folic acid absorption)

  • Later, addition of folic acid (vitamin B9).

This HDT therapy has shown noticeable improvements in Parkinson’s disease symptoms in a short period (1-2weeks or even sooner).


Conclusion

To obtain a correct dose, select a dose of B1 and proceed Stage 1 (for 2-3 weeks), but if we suspect the B1 dose is over , it would cause the tremors or other symptoms worse, immediately stop it for 1-2 weeks or until the symptoms subside, then have a short break, restart B1 therapy at a lower dose.
If the starting dose is under dose, there will be no sign of improvement on the motor or non-motor symptoms. Because t is enough dose in order to kick start the substantial nigra brain cell dopamine function.


The combination of microcurrent acupunture and the B1 therapy get the most benefit from Parkin’s disease because we can start with low dose of B1, we can get the correct dose of B1 more quicker and more effectively.

Some people achieves improvement with the oral form in several months, some people only takes several days. We recommend staying at each dose for six weeks to thoroughly test a level before increasing to the next dosage. The microcurrent acupuncture gives nearly 100% successful rate in the first visit for all patients. Then the patent can undergo the B1 therapy at the same time.


Stage 1:
2-3g of high-dose B1, find the correct dose

Stage 2: (Stage 2 will be considered only after long period of correct dose)
2g (correct dose) of B1 + 1 capsule of B complex + B12 + folic acid (vitamin B9).
This stage 2 carry on two months, then stop for one month. The reason is B6 is not soluble in water and will accumulate in the body.

Excessive Vitamin B1 (Thiamine) usually does not cause serious adverse reactions because it is a water-soluble vitamin, and the body will excrete the excess. However, in very rare cases, excessive intake may cause:

  1. Allergic Reactions: Such as rash or difficulty breathing.

  2. Digestive Issues: Such as nausea or abdominal discomfort.

Certainly. The B vitamins are a group of water-soluble vitamins that play important roles in various aspects such as energy metabolism, nerve function, and skin health. Below are the detailed benefits and possible side effects of each B vitamin:


Benefits & Side effects of B1

Benefits:

  • Helps convert carbohydrates into energy.

  • Supports the normal functioning of the nervous system.

  • Aids in heart function and muscle coordination.

Side Effects:

  • Thiamine is generally considered to have few side effects and is usually safe.

  • High doses may cause mild allergic reactions, such as rash or itching.

  • If high doses cause allergic reactions, stopping use will eliminate the side effects.