B1
B1 Thiamine HCL & B1 Mononitrate
Oral B1 Thiamine HCL - HDT High Dose Thiamine Therapy
Dr Costantini recommended using oral thiamine. He stressed that this should be B1 Thiamine HCL , not B1 mononitrate. Both are synthetic vitamins, but hydrochloride is more water soluble and not likely to build up in the body. The nitrate groups in B1 thiamine mononitrate molecules may accumulate in the kidneys and induce kidney stones by forming insoluble nitrate compounds in high dose.
During oral HDT Therapy, avoid other supplements during the therapy, because other supplement would interfere the function of B1 and interfere this therapy.
No juices, no coffee or tea for one hour with the tablets but with water only.
What is the different between vitamin B1 Thiamine HCL and B1 mononitrate
Vitamin B1 (thiamine) comes in two common forms: thiamine HCl (thiamine hydrochloride) and thiamine mononitrate ( not used in B1 High Dose Therapy HDT). They have slight differences in chemical structure, stability, and absorption:
Chemical Structure and Stability:
Thiamine HCl: Contains hydrochloride, which increases water solubility. This makes it suitable for solutions or injectable forms, allowing for quicker absorption, but it’s more prone to absorbing moisture and can be less stable over time.
Thiamine Mononitrate(not used in B1 Therapy): Contains a nitrate group, making it less absorbent and more stable, which makes it ideal for solid forms (like tablets and capsules) and gives it a longer shelf life.
Bioavailability and Absorption:
Both forms offer similar absorption and bioavailability, but thiamine HCl may absorb slightly faster due to its water solubility.
Thiamine mononitrate is more stable, especially in storage, and is commonly used in oral supplements for its longevity.
Uses:
Thiamine HCl: Often used in injectable or liquid formulas where rapid absorption is needed.
Thiamine Mononitrate: Typically found in tablet or capsule form and is ideal for daily supplements where stability over time is important.
In general, for rapid absorption, thiamine HCl may be preferable, while thiamine mononitrate is often chosen for long-term oral supplements due to its stability.
Thiamine HCl & Thiamine Mononitrate
維他命 B1（即硫胺素）有兩種常見的形式：硫胺素鹽酸鹽（Thiamine HCl）和硫胺素硝酸鹽（Thiamine Mononitrate）不適用於 HDT B1 治療。兩者在化學結構、穩定性和吸收方面有一些細微的差異：
化學結構與穩定性：
硫胺素鹽酸鹽（Thiamine HCl）：含有鹽酸成分，能增加水溶性，適合製成水溶液或注射劑。這使它的吸收速度較快，但在製作過程和儲存時較容易受潮而降低穩定性。
硫胺素硝酸鹽（Thiamine Mononitrate）：由硝酸鹽結構組成，吸水性較低，相對穩定，適合製成固體劑型（例如片劑、膠囊），且保存期限較長。
生物利用度與吸收：
雖然兩者吸收和生物利用度相似，硫胺素鹽酸鹽因為較易溶於水，吸收速度可能較快。
硫胺素硝酸鹽則因穩定性高、吸水性低，較適合在口服補充劑中使用，特別是在長期儲存環境下效果較好。
用途：
硫胺素鹽酸鹽：多用於注射液、溶液配方。
硫胺素硝酸鹽：通常在片劑或膠囊中見到，尤其在不需要即時效果的情況下，如日常保健補充劑。
B1 Allergic Reactions
Although vitamin B1 (thiamine) is generally safe, with excess typically excreted through urine, taking very high doses (such as through injections or large supplements) may lead to rare side effects. Here are some possible reactions:
Allergic Reactions: In rare cases, allergic reactions can occur, with symptoms such as rash, itching, swelling (especially of the face, tongue, or throat), dizziness, or difficulty breathing.
Low Blood Pressure: High-dose thiamine injections have been reported to occasionally cause blood pressure to drop, leading to dizziness or a feeling of weakness.
Gastrointestinal Discomfort: In some cases, high oral doses of vitamin B1 may cause mild gastrointestinal discomfort, like nausea, bloating, or diarrhea.
These side effects are generally very rare, especially with normal dietary or standard supplement intake. If high doses of vitamin B1 are needed, it’s best to do so under a doctor’s supervision.
B1 過敏反應
儘管維生素B1（硫胺素）通常是安全的，且過量通常會通過尿液排出，但在非常高劑量（例如通過注射或大量補充劑攝入）的情況下，可能會引發一些罕見的副作用。以下是可能的反應：
過敏反應：極少數情況下，可能會出現過敏反應，症狀包括皮疹、瘙癢、腫脹（尤其是臉部、舌頭、喉嚨）、頭暈或呼吸困難。
低血壓：有報告顯示，注射高劑量維生素B1可能導致血壓下降，引起頭暈或虛弱感。
腸胃不適：少數情況下，口服高劑量維生素B1可能引起輕微的腸胃不適，如噁心、腹脹或腹瀉。